Zn-Enhanced Asp-Rich Antimicrobial Peptides: N-Terminal Coordination by Zn(II) and Cu(II), Which Distinguishes Cu(II) Binding to Different Peptides

Zn-Enhanced Asp-Rich Antimicrobial Peptides: N-Terminal Coordination by Zn(II) and Cu(II), Which Distinguishes Cu(II) Binding to Different Peptides

The antimicrobial activity of surfactant-associated anionic peptides (SAAPs), which are isolated from the ovine pulmonary surfactant and are selective against the ovine pathogen <i>Mannheimia haemolytica</i>, is strongly enhanced in the presence of Zn(II) ions. Both calorimetry and ITC m...

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Bibliographic Details
Main Authors: Adriana Miller, Agnieszka Matera-Witkiewicz, Aleksandra Mikołajczyk, Joanna Wątły, Dean Wilcox, Danuta Witkowska, Magdalena Rowińska-Żyrek
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
metal-antimicrobial peptide interactions
thermodynamics
Zn(II) and Cu(II) bioinorganic chemistry
Online Access:https://www.mdpi.com/1422-0067/22/13/6971

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https://www.mdpi.com/1422-0067/22/13/6971

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