Generation of megabase-scale deletions, inversions and duplications involving the Contactin-6 gene in mice by CRISPR/Cas9 technology

Generation of megabase-scale deletions, inversions and duplications involving the Contactin-6 gene in mice by CRISPR/Cas9 technology

Abstract Background Copy Number Variation (CNV) of the human CNTN6 gene (encoding the contactin-6 protein), caused by deletions or duplications, is responsible for severe neurodevelopmental impairments, often in combination with facial dysmorphias. Conversely, deleterious point mutations of this gen...

Full description

Bibliographic Details
Main Authors: Alexei N. Korablev, Irina A. Serova, Oleg L. Serov
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Genetics
Subjects:
CRISPR/Cas9 technology
Megabase-scale deletions
Duplications and inversions
Cntn6 gene
Cytoplasmic microinjections into mouse zygotes
Online Access:http://link.springer.com/article/10.1186/s12863-017-0582-7

Internet

http://link.springer.com/article/10.1186/s12863-017-0582-7

Similar Items