Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression

Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression

Garcinol is a polyisoprenylated benzophenone derived from the Garcinia indica fruit that possess potential therapeutic effects such as inhibition of inflammation and tumor expansion. Here, we investigated whether garcinol induces TRAIL sensitization in renal carcinoma cells. Single treatment with ga...

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Bibliographic Details
Main Authors: Seok Kim, Seung Un Seo, Kyoung-Jin Min, Seon Min Woo, Ju-Ock Nam, Peter Kubatka, Shin Kim, Jong-Wook Park, Taeg Kyu Kwon
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
garcinol
TRAIL
c-FLIP
DR5
apoptosis
Online Access:http://www.mdpi.com/1420-3049/23/7/1614

Internet

http://www.mdpi.com/1420-3049/23/7/1614

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