Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease

Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease

Death receptor 3 (DR3) is a tumor necrosis factor receptor superfamily member (TNFRSF25), which is minimally expressed on resting conventional T cells (though readily inducible upon cell activation), yet highly expressed on resting FoxP3+ regulatory T cells (Treg). We recently demonstrated that acti...

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Bibliographic Details
Main Authors: Melissa Mavers, Federico Simonetta, Hidekazu Nishikii, Jessica V. Ribado, Kristina Maas-Bauer, Maite Alvarez, Toshihito Hirai, Mustafa Turkoz, Jeanette Baker, Robert S. Negrin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
regulatory T cells
death receptor 3
TNFRSF25
TNF-like ligand 1A
TNFSF15
graft-versus-host disease
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01624/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01624/full

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