NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis

NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis

Summary: Many metabolic diseases disrupt endoplasmic reticulum (ER) homeostasis, but little is known about how metabolic activity is communicated to the ER. Here, we show in hepatocytes and other metabolically active cells that decreasing the availability of substrate for the tricarboxylic acid (TCA...

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Bibliographic Details
Main Authors: Erica R. Gansemer, Kyle S. McCommis, Michael Martino, Abdul Qaadir King-McAlpin, Matthew J. Potthoff, Brian N. Finck, Eric B. Taylor, D. Thomas Rutkowski
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:iScience
Subjects:
biological sciences
cell biology
functional aspects of cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220303011

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http://www.sciencedirect.com/science/article/pii/S2589004220303011

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