Safety and immunogenicity of an HIV-1 gag DNA vaccine with or without IL-12 and/or IL-15 plasmid cytokine adjuvant in healthy, HIV-1 uninfected adults.

Safety and immunogenicity of an HIV-1 gag DNA vaccine with or without IL-12 and/or IL-15 plasmid cytokine adjuvant in healthy, HIV-1 uninfected adults.

DNA vaccines are a promising approach to vaccination since they circumvent the problem of vector-induced immunity. DNA plasmid cytokine adjuvants have been shown to augment immune responses in small animals and in macaques.We performed two first in human HIV vaccine trials in the US, Brazil and Thai...

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Bibliographic Details
Main Authors: Spyros A Kalams, Scott Parker, Xia Jin, Marnie Elizaga, Barbara Metch, Maggie Wang, John Hural, Michael Lubeck, John Eldridge, Massimo Cardinali, William A Blattner, Magda Sobieszczyk, Vinai Suriyanon, Artur Kalichman, David B Weiner, Lindsey R Baden, NIAID HIV Vaccine Trials Network
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3252307?pdf=render

Internet

http://europepmc.org/articles/PMC3252307?pdf=render

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