Applicable or non-applicable: investigations of clinical heterogeneity in systematic reviews

Abstract Background Clinical heterogeneity can be defined as differences in participant characteristics, types or timing of outcome measurements and intervention characteristics. Clinical heterogeneity in systematic reviews has the possibility to significantly affect statistical heterogeneity leadin...

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Bibliographic Details
Main Authors: Laura E. Chess, Joel J. Gagnier
Format: Article
Language:English
Published: BMC 2016-02-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12874-016-0121-7