Nasal Delivery of D-Penicillamine Hydrogel Upregulates a Disintegrin and Metalloprotease 10 Expression via Melatonin Receptor 1 in Alzheimer’s Disease Models

Nasal Delivery of D-Penicillamine Hydrogel Upregulates a Disintegrin and Metalloprotease 10 Expression via Melatonin Receptor 1 in Alzheimer’s Disease Models

Alzheimer’s disease (AD) is a type of neurodegenerative disease that is associated with the accumulation of amyloid plaques. Increasing non-amyloidogenic processing and/or manipulating amyloid precursor protein signaling could reduce AD amyloid pathology and cognitive impairment. D-penicillamine (D-...

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Bibliographic Details
Main Authors: Manli Zhong, Hejia Kou, Pu Zhao, Wei Zheng, He Xu, Xiaoyu Zhang, Wang Lan, Chuang Guo, Tao Wang, Feng Guo, Zhanyou Wang, Huiling Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
ADAM10
amyloid-β peptide
D-penicillamine
melatonin receptor 1
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.660249/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.660249/full

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