CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment

CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment

Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla. Here, we describe an unanticipated contribution of CCR7 to intrathymic Treg generation. Ccr...

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Bibliographic Details
Main Authors: Zicheng Hu, Yu Li, Annemarie Van Nieuwenhuijze, Hilary J. Selden, Angela M. Jarrett, Anna G. Sorace, Thomas E. Yankeelov, Adrian Liston, Lauren I.R. Ehrlich
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
CCR7
regulatory T cells
dendritic cells
chemokine receptor
thymocyte development
thymus
central tolerance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312779

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http://www.sciencedirect.com/science/article/pii/S2211124717312779

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