CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment
Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla. Here, we describe an unanticipated contribution of CCR7 to intrathymic Treg generation. Ccr...
Main Authors: | Zicheng Hu, Yu Li, Annemarie Van Nieuwenhuijze, Hilary J. Selden, Angela M. Jarrett, Anna G. Sorace, Thomas E. Yankeelov, Adrian Liston, Lauren I.R. Ehrlich |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-10-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717312779 |
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