White matter microstructure, white matter lesions, and hypertension: An examination of early surrogate markers of vascular-related brain change in midlife

Objective: We examined imaging surrogates of white matter microstructural abnormalities which may precede white matter lesions (WML) and represent a relevant marker of cerebrovascular injury in adults in midlife. Methods: In 698 community-dwelling adults (mean age 50 years ±3.5 SD) from the Coronary...

Full description

Bibliographic Details
Main Authors: Thaddeus Haight, R. Nick Bryan, Guray Erus, Meng-Kang Hsieh, Christos Davatzikos, Ilya Nasrallah, Mark D'Esposito, David R. Jacobs, Jr, Cora Lewis, Pamela Schreiner, Stephen Sidney, Osorio Meirelles, Lenore J. Launer
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:NeuroImage: Clinical
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158218300640