Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells

Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells

We have used three established human glioblastoma (GBM) cell lines—U87MG, A172, and T98G—as cellular systems to examine the plasticity of the drug-induced GBM cell phenotype, focusing on two clinical drugs, the phosphodiesterase PDE10A inhibitor Mardepodect and the multi-kinase inhibitor Regorafenib...

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Bibliographic Details
Main Authors: Vladimir Shapovalov, Liliya Kopanitsa, Lavinia-Lorena Pruteanu, Graham Ladds, David S. Bailey
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
glioblastoma
drug-inducible gene expression
Mardepodect
Regorafenib
drug targets
tumor antigens
Online Access:https://www.mdpi.com/2072-6694/13/15/3780

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https://www.mdpi.com/2072-6694/13/15/3780

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