Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A

Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A

Effective therapy of atherosclerotic complications in patients with chronic kidney disease (CKD) is an unmet clinical need. Cardiovascular events are the most common cause of death. At a glomerular filtration rate ≤60 ml/min, these events are increased also after correction for common risk factors....

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Bibliographic Details
Main Authors: Johannes Nordlohne, MA, Alexandra Helmke, MA, Shuwang Ge, MD, Song Rong, MD, Rongjun Chen, MD, Ari Waisman, PhD, Hermann Haller, MD, Sibylle von Vietinghoff, MD
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:JACC: Basic to Translational Science
Subjects:
atherosclerosis
chronic kidney disease
interleukin 17
macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X17302346

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http://www.sciencedirect.com/science/article/pii/S2452302X17302346

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