The FG Loop of PD-1 Serves as a “Hotspot” for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy

The FG Loop of PD-1 Serves as a “Hotspot” for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy

Summary: Programmed cell death 1 (PD-1)/PD-1 ligand-1 (PD-L1)-blocking monoclonal antibodies (mAbs) have taken center stage for tumor immune checkpoint therapy. Identification of the “hotspots” on PD-1 for mAbs will help to develop next-generation oral deliverable agents with long-lasting efficacy....

Full description

Bibliographic Details
Main Authors: Danqing Chen, Shuguang Tan, Hao Zhang, Haiyuan Wang, Weiwu He, Rui Shi, Zhou Tong, Jianhua Zhu, Hao Cheng, Shan Gao, Yan Chai, Jianxun Qi, Minghui Xiao, Jinghua Yan, George F. Gao
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219300835

Internet

http://www.sciencedirect.com/science/article/pii/S2589004219300835

Similar Items