The Bacteriostatic Activity of 2-Phenylethanol Derivatives Correlates with Membrane Binding Affinity

The Bacteriostatic Activity of 2-Phenylethanol Derivatives Correlates with Membrane Binding Affinity

The hydrophobic tails of aliphatic primary alcohols do insert into the hydrophobic core of a lipid bilayer. Thereby, they disrupt hydrophobic interactions between the lipid molecules, resulting in a decreased lipid order, i.e., an increased membrane fluidity. While aromatic alcohols, such as 2-pheny...

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Bibliographic Details
Main Authors: Isabel S. Kleinwächter, Stefanie Pannwitt, Alessia Centi, Nadja Hellmann, Eckhard Thines, Tristan Bereau, Dirk Schneider
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Membranes
Subjects:
2-phenylethanol
phenylacetic acid
phenyllactic acid
methyl phenylacetate
Tyrosol
biomembranes
Online Access:https://www.mdpi.com/2077-0375/11/4/254

Internet

https://www.mdpi.com/2077-0375/11/4/254

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