Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy

Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy

IgA nephropathy is a chronic renal disease characterized by mesangial immunodeposits that contain autoantigen, which is aberrantly glycosylated IgA1 with some hinge-region O-glycans deficient in galactose. Macroscopic hematuria during an upper respiratory tract infection is common among patients wit...

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Bibliographic Details
Main Authors: Koshi Yamada, Zhi-Qiang Huang, Milan Raska, Colin Reily, Joshua C. Anderson, Hitoshi Suzuki, Hiroyuki Ueda, Zina Moldoveanu, Krzysztof Kiryluk, Yusuke Suzuki, Robert J. Wyatt, Yasuhiko Tomino, Ali G. Gharavi, Amy Weinmann, Bruce A. Julian, Christopher D. Willey, Jan Novak
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Kidney International Reports
Subjects:
aberrant glycosylation
autoantigen
IgA1
IgA nephropathy
O-glycans
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024917303005

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http://www.sciencedirect.com/science/article/pii/S2468024917303005

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