Hyperglycemia Promotes TMPRSS2-ERG Gene Fusion in Prostate Cancer Cells via Upregulating Insulin-Like Growth Factor-Binding Protein-2

Hyperglycemia Promotes TMPRSS2-ERG Gene Fusion in Prostate Cancer Cells via Upregulating Insulin-Like Growth Factor-Binding Protein-2

BackgroundEpidemiologic evidence shows that obesity is associated with a greater risk of aggressive prostate cancer (PCa) and PCa-specific mortality and this is observed mainly in men with the TMPRSS2-ERG gene fusion. Obesity is often associated with comorbid conditions such as type 2 diabetes and h...

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Bibliographic Details
Main Authors: Jeff M. P. Holly, Jessica Broadhurst, Rehanna Mansor, Amit Bahl, Claire M. Perks
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Endocrinology
Subjects:
prostate cancer
insulin-like growth factor-binding protein-2
TMPRSS2-ERG
hyperglycemia
type II diabetes
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00305/full

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http://journal.frontiersin.org/article/10.3389/fendo.2017.00305/full

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