Comprehensive Exonic Sequencing of Hemiplegic Migraine-Related Genes in a Cohort of Suspected Probands Identifies Known and Potential Pathogenic Variants

Comprehensive Exonic Sequencing of Hemiplegic Migraine-Related Genes in a Cohort of Suspected Probands Identifies Known and Potential Pathogenic Variants

Hemiplegic migraine (HM) is a rare migraine disorder with aura subtype including temporary weakness and visual, sensory, and/or speech symptoms. To date, three main genes—<i>CACNA1A</i>, <i>ATP1A2</i>, and <i>SCN1A</i>—have been found to cause HM. These encode ion...

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Bibliographic Details
Main Authors: Heidi G. Sutherland, Neven Maksemous, Cassie L. Albury, Omar Ibrahim, Robert A. Smith, Rod A. Lea, Larisa M. Haupt, Bronwyn Jenkins, Benjamin Tsang, Lyn R. Griffiths
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
familial hemiplegic migraine
migraine
paroxysmal movement disorders
whole exome sequencing
ion channel genes
mutations
Online Access:https://www.mdpi.com/2073-4409/9/11/2368

Internet

https://www.mdpi.com/2073-4409/9/11/2368

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