USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase

USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase

In the endoplasmic reticulum (ER), misfolded and unfolded proteins are eliminated by a process called ER-associated protein degradation (ERAD) in order to maintain cell homeostasis. In the ERAD pathway, several ER-localized E3 ubiquitin ligases target ERAD substrate proteins for ubiquitination and s...

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Bibliographic Details
Main Authors: Kumi Harada, Masako Kato, Nobuhiro Nakamura
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:International Journal of Molecular Sciences
Subjects:
deubiquitinating enzyme
endoplasmic reticulum
ERAD
membrane protein
ubiquitin ligase
Online Access:http://www.mdpi.com/1422-0067/17/11/1829

Internet

http://www.mdpi.com/1422-0067/17/11/1829

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