Development of the first reference antibody panel for qualification and validation of cytokine release assay platforms – Report of an international collaborative study

Development of the first reference antibody panel for qualification and validation of cytokine release assay platforms – Report of an international collaborative study

Immunomodulatory therapeutics such as monoclonal antibodies (mAb) carry an inherent risk of undesired immune reactions. One such risk is cytokine release syndrome (CRS), a rapid systemic inflammatory response characterized by the secretion of pro-inflammatory cytokines from immune cells. It is cruci...

Full description

Bibliographic Details
Main Authors: Sandrine Vessillier, Madeline Fort, Lynn O'Donnell, Heather Hinton, Kimberly Nadwodny, Joseph Piccotti, Peter Rigsby, Karin Staflin, Richard Stebbings, Divya Mekala, Aarron Willingham, Babette Wolf
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cytokine: X
Subjects:
Cytokine release assay
Hazard identification
Cytokine storm
Antibody therapeutics
Reference reagents
Online Access:http://www.sciencedirect.com/science/article/pii/S2590153220300227

Internet

http://www.sciencedirect.com/science/article/pii/S2590153220300227

Similar Items