Aspirin down Regulates Hepcidin by Inhibiting NF-κB and IL6/JAK2/STAT3 Pathways in BV-2 Microglial Cells Treated with Lipopolysaccharide

Aspirin down Regulates Hepcidin by Inhibiting NF-κB and IL6/JAK2/STAT3 Pathways in BV-2 Microglial Cells Treated with Lipopolysaccharide

Aspirin down regulates transferrin receptor 1 (TfR1) and up regulates ferroportin 1 (Fpn1) and ferritin expression in BV-2 microglial cells treated without lipopolysaccharides (LPS), as well as down regulates hepcidin and interleukin 6 (IL-6) in cells treated with LPS. However, the relevant mechanis...

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Bibliographic Details
Main Authors: Wan-Ying Li, Fei-Mi Li, Yu-Fu Zhou, Zhong-Min Wen, Juan Ma, Ke Ya, Zhong-Ming Qian
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:International Journal of Molecular Sciences
Subjects:
aspirin
hepcidin
P65 (nuclear factor-κB)
IL-6/JAK2/STAT3 pathway
lipopolysaccharide (LPS)
nitric oxide (NO)
iron regulatory protein 1 (IRP1)
Online Access:http://www.mdpi.com/1422-0067/17/12/1921

Internet

http://www.mdpi.com/1422-0067/17/12/1921

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