Non-photoreceptor Expression of Tulp1 May Contribute to Extensive Retinal Degeneration in Tulp1-/- Mice

Non-photoreceptor Expression of Tulp1 May Contribute to Extensive Retinal Degeneration in Tulp1-/- Mice

Mutations in tubby like protein 1 gene (TULP1) are causative of early-onset recessive inherited retinal degenerations (IRDs); similarly, the Tulp1-/- mouse is also characterized by a rapid IRD. Tulp1 mRNA and protein expression was analyzed in wild type mouse retinas and expression data sets (NCBI)...

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Bibliographic Details
Main Authors: Arpad Palfi, Adlet Yesmambetov, Pete Humphries, Karsten Hokamp, G. Jane Farrar
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroscience
Subjects:
retina
degeneration
mouse model
inherited
Tulp1
disease
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00656/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00656/full

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