Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke

Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke

Abstract Background Ischemic stroke is a leading cause of disability worldwide and characteristically accompanied by downregulation of the Wnt/β-catenin signaling. Activation of Wnt/β-catenin signaling emerges to attenuate neuroinflammation after ischemic stroke; however, its effect on modulating mi...

Full description

Bibliographic Details
Main Authors: Degang Song, Xiangjian Zhang, Junmin Chen, Xiaoxia Liu, Jing Xue, Lan Zhang, Xifa Lan
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
Cerebral ischemia
WNT/β-catenin
TWS119
Microglial polarization
Neuroinflammation
Neurological recovery
Online Access:https://doi.org/10.1186/s12974-019-1660-8

Internet

https://doi.org/10.1186/s12974-019-1660-8

Similar Items