Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin-3A

Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin-3A

Small RhoGTPases, such as Cdc42 and RhoA, are key players in integrating external cues and intracellular signaling pathways that regulate growth cone (GC) motility. Indeed, Cdc42 is involved in actin polymerization and filopodia formation, whereas RhoA induces GC collapse and neurite retraction thro...

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Bibliographic Details
Main Authors: Federico eIseppon, Luisa Maria Rosaria Napolitano, Vincent eTorre, Dan eCojoc
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cdc42
RhoA
FRET
semaphorin3A
Local stimulation
growth cone retraction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00333/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00333/full

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