T Cell-Derived IL-17A Induces Vascular Dysfunction via Perivascular Fibrosis Formation and Dysregulation of ⋅NO/cGMP Signaling

T Cell-Derived IL-17A Induces Vascular Dysfunction via Perivascular Fibrosis Formation and Dysregulation of ⋅NO/cGMP Signaling

Aims. The neutrophil recruiting cytokine Interleukin-17A (IL-17A) is a key component in vascular dysfunction and arterial hypertension. Moreover, IL-17A has a central role for the vascular infiltration of myeloid cells into the arterial wall in Angiotensin II-induced vascular inflammation. The inten...

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Bibliographic Details
Main Authors: Rebecca Schüler, Panagiotis Efentakis, Johannes Wild, Jérémy Lagrange, Venkata Garlapati, Michael Molitor, Sabine Kossmann, Matthias Oelze, Paul Stamm, Huige Li, Katrin Schäfer, Thomas Münzel, Andreas Daiber, Ari Waisman, Philip Wenzel, Susanne Helena Karbach
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2019/6721531

Internet

http://dx.doi.org/10.1155/2019/6721531

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