Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta

Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta

Osteogenesis imperfecta (OI) is characterized by short stature, skeletal deformities, low bone mass, and motor deficits. A subset of OI patients also present with joint hypermobility; however, the role of tendon dysfunction in OI pathogenesis is largely unknown. Using the Crtap-/- mouse model of sev...

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Bibliographic Details
Main Authors: Matthew William Grol, Nele A Haelterman, Joohyun Lim, Elda M Munivez, Marilyn Archer, David M Hudson, Sara F Tufa, Douglas R Keene, Kevin Lei, Dongsu Park, Cole D Kuzawa, Catherine G Ambrose, David R Eyre, Brendan H Lee
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
osteogenesis imperfecta
tendon
progenitors
collagen
behavior
Online Access:https://elifesciences.org/articles/63488

Internet

https://elifesciences.org/articles/63488

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