Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.

Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.

The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion of the antiviral T cell response in chronic hepatit...

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Bibliographic Details
Main Authors: Gaia Nebbia, Dimitra Peppa, Anna Schurich, Pooja Khanna, Harsimran D Singh, Yang Cheng, William Rosenberg, Geoffrey Dusheiko, Richard Gilson, Joanne ChinAleong, Patrick Kennedy, Mala K Maini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3480425?pdf=render

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http://europepmc.org/articles/PMC3480425?pdf=render

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