Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans

Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans

Abstract Background Genome-wide association studies are useful for discovering genotype–phenotype associations but are limited because they require large cohorts to identify a signal, which can be population-specific. Mapping genetic variation to genes improves power and allows the effects of both p...

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Bibliographic Details
Main Authors: Assaf Gottlieb, Roxana Daneshjou, Marianne DeGorter, Stephane Bourgeois, Peter J. Svensson, Mia Wadelius, Panos Deloukas, Stephen B. Montgomery, Russ B. Altman
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Genome Medicine
Subjects:
Pharmacogenomics
Warfarin dose
International Warfarin Pharmacogenetics Consortium
African Americans
Online Access:http://link.springer.com/article/10.1186/s13073-017-0495-0

Internet

http://link.springer.com/article/10.1186/s13073-017-0495-0

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