Galectin 3 Deficiency Alters Chondrocyte Primary Cilium Formation and Exacerbates Cartilage Destruction via Mitochondrial Apoptosis

Galectin 3 Deficiency Alters Chondrocyte Primary Cilium Formation and Exacerbates Cartilage Destruction via Mitochondrial Apoptosis

Mechanical overload and aging are the main risk factors of osteoarthritis (OA). Galectin 3 (GAL3) is important in the formation of primary cilia, organelles that are able to sense mechanical stress. The objectives were to evaluate the role of GAL3 in chondrocyte primary cilium formation and in OA in...

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Bibliographic Details
Main Authors: Narjès Hafsia, Marine Forien, Félix Renaudin, Delphine Delacour, Pascal Reboul, Peter Van Lent, Martine Cohen-Solal, Frédéric Lioté, Françoise Poirier, Hang Korng Ea
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
galectin 3
primary cilium
chondrocyte
osteoarthritis
mechanical stress
apoptosis
Online Access:https://www.mdpi.com/1422-0067/21/4/1486

Internet

https://www.mdpi.com/1422-0067/21/4/1486

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