Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

Objective: Given that cellular O-GlcNAcylation levels are thought to be real-time measures of cellular nutrient status and dysregulated O-GlcNAc signaling is associated with insulin resistance, we evaluated the role of O-GlcNAc transferase (OGT), the enzyme that mediates O-GlcNAcylation, in skeletal...

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Bibliographic Details
Main Authors: Hao Shi, Alexander Munk, Thomas S. Nielsen, Morgan R. Daughtry, Louise Larsson, Shize Li, Kasper F. Høyer, Hannah W. Geisler, Karolina Sulek, Rasmus Kjøbsted, Taylor Fisher, Marianne M. Andersen, Zhengxing Shen, Ulrik K. Hansen, Eric M. England, Zhiyong Cheng, Kurt Højlund, Jørgen F.P. Wojtaszewski, Xiaoyong Yang, Matthew W. Hulver, Richard F. Helm, Jonas T. Treebak, David E. Gerrard
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817311006

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http://www.sciencedirect.com/science/article/pii/S2212877817311006

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