High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats

High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats

Abstract Background Chemotherapy-induced peripheral neurotoxicity (CIPN) is a severe adverse effect in patients receiving antitumor agents, and no effective treatment is available. Although the mechanisms responsible for the development of CIPN are poorly understood, recent findings make neuroinflam...

Full description

Bibliographic Details
Main Authors: Cristina Meregalli, Ivan Marjanovic, Carla Scali, Laura Monza, Nadia Spinoni, Cristina Galliani, Rinaldo Brivio, Alessia Chiorazzi, Elisa Ballarini, Virginia Rodriguez-Menendez, Valentina Alda Carozzi, Paola Alberti, Giulia Fumagalli, Eleonora Pozzi, Annalisa Canta, Marina Quartu, Chiara Briani, Norberto Oggioni, Paola Marmiroli, Guido Cavaletti
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
Bortezomib
Peripheral neurotoxicity
Allodynia
Human intravenous immunoglobulin (IVIG)
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-018-1270-x

Internet

http://link.springer.com/article/10.1186/s12974-018-1270-x

Similar Items