5-Phenoxy Primaquine Analogs and the Tetraoxane Hybrid as Antimalarial Agents

5-Phenoxy Primaquine Analogs and the Tetraoxane Hybrid as Antimalarial Agents

The rapid emergence of drug resistance to the current antimalarial agents has led to the urgent need for the discovery of new and effective compounds. In this work, a series of 5-phenoxy primaquine analogs with 8-aminoquinoline core (<b>7a</b>–<b>7h</b>) was synthesized and i...

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Bibliographic Details
Main Authors: Somruedee Jansongsaeng, Nitipol Srimongkolpithak, Jutharat Pengon, Sumalee Kamchonwongpaisan, Tanatorn Khotavivattana
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
primaquine
structure–activity relationship
tetraoxane
hybrid drug
antimalarial activity
heme polymerization inhibition activity
Online Access:https://www.mdpi.com/1420-3049/26/13/3991

Internet

https://www.mdpi.com/1420-3049/26/13/3991

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