Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts

Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts

<p>Abstract</p> <p>Background</p> <p>Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM...

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Bibliographic Details
Main Authors: Larsson-Callerfelt Anna-Karin, Hallgren Oskar, Andersson-Sjöland Annika, Thiman Lena, Björklund Johan, Kron Josefine, Nihlberg Kristian, Bjermer Leif, Löfdahl Claes-Göran, Westergren-Thorsson Gunilla
Format: Article
Language:English
Published: BMC 2013-02-01
Series:Respiratory Research
Subjects:
Chronic obstructive pulmonary disease
Collagen I
Fibroblast
Prostacyclin
Proteoglycans
Decorin
Biglycan
Proliferation
Fibroblast gel contraction
Transforming growth factor β
Online Access:http://respiratory-research.com/content/14/1/21

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http://respiratory-research.com/content/14/1/21

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