Polyol pathway and modulation of ischemia-reperfusion injury in Type 2 diabetic BBZ rat hearts

<p>Abstract</p> <p>We investigated the role of polyol pathway enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH) in mediating injury due to ischemia-reperfusion (IR) in Type 2 diabetic BBZ rat hearts. Specifically, we investigated, (a) changes in glucose flux via cardia...

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Bibliographic Details
Main Authors: Guberski Dennis, Oates Peter J, Ananthakrishnan Radha, Hwang Yuying C, Li Qing, Ramasamy Ravichandran
Format: Article
Language:English
Published: BMC 2008-10-01
Series:Cardiovascular Diabetology
Online Access:http://www.cardiab.com/content/7/1/33