Inhibition of Histone Deacetylase by Butyrate Protects Rat Liver from Ischemic Reperfusion Injury

Inhibition of Histone Deacetylase by Butyrate Protects Rat Liver from Ischemic Reperfusion Injury

We showed previously that pretreatment of butyrate, which is an endogenous histone deacetylase (HDAC) inhibitor normally fermented from undigested fiber by intestinal microflora, seriously alleviated ischemia reperfusion (I/R)-induced liver injury by inhibiting the nuclear factor κB (NF-κB) pathway....

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Bibliographic Details
Main Authors: Jie Sun, Qiujv Wu, Huiling Sun, Yingli Qiao
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:International Journal of Molecular Sciences
Subjects:
reperfusion injury
histone acetylation
histone deacetylase
butyrate
Online Access:http://www.mdpi.com/1422-0067/15/11/21069

Internet

http://www.mdpi.com/1422-0067/15/11/21069

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