Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth

Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth

Summary: Densely arranged N-linked glycans shield the HIV-1 envelope (Env) trimer from antibody recognition. Strain-specific breaches in this shield (glycan holes) can be targets of vaccine-induced neutralizing antibodies that lack breadth. To understand the interplay between glycan holes and neutra...

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Bibliographic Details
Main Authors: Kshitij Wagh, Edward F. Kreider, Yingying Li, Hannah J. Barbian, Gerald H. Learn, Elena Giorgi, Peter T. Hraber, Timothy G. Decker, Andrew G. Smith, Marcos V. Gondim, Lindsey Gillis, Jamie Wandzilak, Gwo-Yu Chuang, Reda Rawi, Fangping Cai, Pierre Pellegrino, Ian Williams, Julie Overbaugh, Feng Gao, Peter D. Kwong, Barton F. Haynes, George M. Shaw, Persephone Borrow, Michael S. Seaman, Beatrice H. Hahn, Bette Korber
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718315584

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http://www.sciencedirect.com/science/article/pii/S2211124718315584

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