Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands

Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands

The cytotoxic activity of several serotonin transporter (SERT) inhibitors and subtype of serotonin receptor 1A (5-HT1A receptor) ligands have been examined in androgen-insensitive human PC-3 prostate and neuroblastoma SH-SY5Y cancer cells. Almost all of the studied compounds (except 5-HT1A receptor...

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Bibliographic Details
Main Authors: Jarosław Walory, Lidia Mielczarek, Małgorzata Jarończyk, Mirosława Koronkiewicz, Jerzy Kossakowski, Ryszard Bugno, Andrzej J. Bojarski, Zdzisław Chilmonczyk
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
5-HT1A receptor
apoptosis
cancer
cytotoxic activity
serotonin ligands
SH-SY5Y
SSRI
S14506
PC-3
Online Access:http://www.mdpi.com/1422-0067/19/10/3260

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http://www.mdpi.com/1422-0067/19/10/3260

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