Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle

Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle

Skeletal muscle-derived PW1pos/Pax7neg interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofiber...

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Bibliographic Details
Main Authors: Fiona C. Lewis, BSc, PhD, Beverley J. Cottle, BSc, PhD, Victoria Shone, BSc, MSc, PhD, Giovanna Marazzi, MD, David Sassoon, PhD, Cheyenne C.S. Tseng, MD, Patricia Y.W. Dankers, PhD, Steven A.J. Chamuleau, MD, PhD, Bernardo Nadal-Ginard, MD, PhD, Georgina M. Ellison-Hughes, BSc, PhD
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:JACC: Basic to Translational Science
Subjects:
allogeneic progenitor cells
growth factors
PICs
porcine preclinical model
regeneration
skeletal muscle
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X17302255

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http://www.sciencedirect.com/science/article/pii/S2452302X17302255

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