Functional Characterization of 21 Rare Allelic <em>CYP1A2</em> Variants Identified in a Population of 4773 Japanese Individuals by Assessing Phenacetin <em>O</em>-Deethylation

Functional Characterization of 21 Rare Allelic <em>CYP1A2</em> Variants Identified in a Population of 4773 Japanese Individuals by Assessing Phenacetin <em>O</em>-Deethylation

Cytochrome P450 1A2 (CYP1A2), which accounts for approximately 13% of the total hepatic cytochrome content, catalyzes the metabolic reactions of approximately 9% of frequently used drugs, including theophylline and olanzapine. Substantial inter-individual differences in enzymatic activity have been...

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Bibliographic Details
Main Authors: Masaki Kumondai, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, Yuya Nakanishi, Shuki Yamazaki, Akiko Ueda, Sakae Saito, Shu Tadaka, Kengo Kinoshita, Daisuke Saigusa, Tomoki Nakayoshi, Akifumi Oda, Noriyasu Hirasawa, Masahiro Hiratsuka
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Journal of Personalized Medicine
Subjects:
cytochrome P450 1A2
genetic variation
phenacetin
drug metabolism
Online Access:https://www.mdpi.com/2075-4426/11/8/690

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https://www.mdpi.com/2075-4426/11/8/690

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