Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo

Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo

Chronic bone degenerative diseases represent a major threat to the health and well-being of the population, particularly those with advanced age. This study isolated exosomes (EXO), natural nano-particles, from dendritic cells, the “directors” of the immune response, to examine the immunobiology of...

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Bibliographic Details
Main Authors: Mahmoud Elashiry, Mohamed M. Elashiry, Ranya Elsayed, Mythily Rajendran, Carol Auersvald, Rana Zeitoun, Mohammad H. Rashid, Roxan Ara, Mohamed M. Meghil, Yutao Liu, Ali S. Arbab, Roger M. Arce, Mark Hamrick, Mohammed Elsalanty, Marshall Brendan, Rafal Pacholczyk, Christopher W. Cutler
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Extracellular Vesicles
Subjects:
(mesh): dendritic cells
exosomes
inflammation
periodontitis
alveolar bone loss
Online Access:http://dx.doi.org/10.1080/20013078.2020.1795362

Internet

http://dx.doi.org/10.1080/20013078.2020.1795362

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