Local Mechanisms for Loud Sound-Enhanced Aminoglycoside Entry into Outer Hair Cells

Local Mechanisms for Loud Sound-Enhanced Aminoglycoside Entry into Outer Hair Cells

Loud sound exposure exacerbates aminoglycoside ototoxicity, increasing the risk of permanent hearing loss and degrading the quality of life in affected individuals. We previously reported that loud sound exposure induces temporary threshold shifts (TTS) and enhances uptake of aminoglycosides, like g...

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Bibliographic Details
Main Authors: Hongzhe eLi, Allan eKachelmeier, David eFurness, Peter Stephen Steyger
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ototoxicity
Cellular uptake
aminoglycoside
Outer hair cells
Auditory function
GTTR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00130/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00130/full

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