Biochemical consequences of two clinically relevant ND-gene mutations in Escherichia coli respiratory complex I

Biochemical consequences of two clinically relevant ND-gene mutations in Escherichia coli respiratory complex I

Abstract NADH:ubiquinone oxidoreductase (respiratory complex I) plays a major role in energy metabolism by coupling electron transfer from NADH to quinone with proton translocation across the membrane. Complex I deficiencies were found to be the most common source of human mitochondrial dysfunction...

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Bibliographic Details
Main Authors: Franziska Nuber, Johannes Schimpf, Jean-Paul di Rago, Déborah Tribouillard-Tanvier, Vincent Procaccio, Marie-Laure Martin-Negrier, Aurélien Trimouille, Olivier Biner, Christoph von Ballmoos, Thorsten Friedrich
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-91631-3

Internet

https://doi.org/10.1038/s41598-021-91631-3

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