Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model

Background. The nephroprotective effect of vitamins E and C or losartan against cisplatin (CP)- induced nephrotoxicity when they are accompanied by estrogen was investigated. Methods. The ovariectomized rats received estradiol valerate for two weeks. At the end of the first week, a single dose of CP...

Full description

Bibliographic Details
Main Authors: Mehdi Nematbakhsh, Zahra Pezeshki, Fatemeh Eshraghi-Jazi, Farzaneh Ashrafi, Hamid Nasri, Ardeshir Talebi, Tahereh Safari, Maryam Haghighi, Azam Mansouri
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:International Journal of Nephrology
Online Access:http://dx.doi.org/10.1155/2012/284896