Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model
Background. The nephroprotective effect of vitamins E and C or losartan against cisplatin (CP)- induced nephrotoxicity when they are accompanied by estrogen was investigated. Methods. The ovariectomized rats received estradiol valerate for two weeks. At the end of the first week, a single dose of CP...
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Series: | International Journal of Nephrology |
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doaj-266cda21d401479fbaa3b470c45420d82020-11-25T01:27:09ZengHindawi LimitedInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/284896284896Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat ModelMehdi Nematbakhsh0Zahra Pezeshki1Fatemeh Eshraghi-Jazi2Farzaneh Ashrafi3Hamid Nasri4Ardeshir Talebi5Tahereh Safari6Maryam Haghighi7Azam Mansouri8Water and Electrolytes Research Center, Isfahan University of Medical Sciences, HezarJerib Avenue, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, HezarJerib Avenue, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, HezarJerib Avenue, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, HezarJerib Avenue, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, HezarJerib Avenue, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, HezarJerib Avenue, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, HezarJerib Avenue, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, HezarJerib Avenue, Isfahan 81745, IranWater and Electrolytes Research Center, Isfahan University of Medical Sciences, HezarJerib Avenue, Isfahan 81745, IranBackground. The nephroprotective effect of vitamins E and C or losartan against cisplatin (CP)- induced nephrotoxicity when they are accompanied by estrogen was investigated. Methods. The ovariectomized rats received estradiol valerate for two weeks. At the end of the first week, a single dose of CP (7 mg/kg, IP) was also administered, and they received placebo (group 1), vitamin E (group 2), vitamin C (group 3), or losartan (group 4) every day during the second week, and they were compared with another three control groups. Results. CP alone increased the serum levels of blood urea nitrogen (BUN), creatinine (Cr), and kidney tissue damage score (KTDS), significantly (P<0.05), however at the presence of estradiol and CP, vitamin C, vitamin E, or losartan not only did not decrease these parameters, but also increased them significantly (P<0.05). The serum level of superoxidase dismutase (SOD) was reduced by CP (P<0.05), but it was increased when estradiol or estradiol plus vitamin C or losartan were added (P<0.05). Conclusion. The particular pharmacological dose of estrogen used in this study abolish the nephroprotective effects vitamins C and E or losartan against CP-induced nephrotoxicity.http://dx.doi.org/10.1155/2012/284896 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mehdi Nematbakhsh Zahra Pezeshki Fatemeh Eshraghi-Jazi Farzaneh Ashrafi Hamid Nasri Ardeshir Talebi Tahereh Safari Maryam Haghighi Azam Mansouri |
spellingShingle |
Mehdi Nematbakhsh Zahra Pezeshki Fatemeh Eshraghi-Jazi Farzaneh Ashrafi Hamid Nasri Ardeshir Talebi Tahereh Safari Maryam Haghighi Azam Mansouri Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model International Journal of Nephrology |
author_facet |
Mehdi Nematbakhsh Zahra Pezeshki Fatemeh Eshraghi-Jazi Farzaneh Ashrafi Hamid Nasri Ardeshir Talebi Tahereh Safari Maryam Haghighi Azam Mansouri |
author_sort |
Mehdi Nematbakhsh |
title |
Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model |
title_short |
Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model |
title_full |
Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model |
title_fullStr |
Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model |
title_full_unstemmed |
Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model |
title_sort |
vitamin e, vitamin c, or losartan is not nephroprotectant against cisplatin-induced nephrotoxicity in presence of estrogen in ovariectomized rat model |
publisher |
Hindawi Limited |
series |
International Journal of Nephrology |
issn |
2090-214X 2090-2158 |
publishDate |
2012-01-01 |
description |
Background. The nephroprotective effect of vitamins E and C or losartan against cisplatin (CP)- induced nephrotoxicity when they are accompanied by estrogen was investigated. Methods. The ovariectomized rats received estradiol valerate for two weeks. At the end of the first week, a single dose of CP (7 mg/kg, IP) was also administered, and they received placebo (group 1), vitamin E (group 2), vitamin C (group 3), or losartan (group 4) every day during the second week, and they were compared with another three control groups. Results. CP alone increased the serum levels of blood urea nitrogen (BUN), creatinine (Cr), and kidney tissue damage score (KTDS), significantly (P<0.05), however at the presence of estradiol and CP, vitamin C, vitamin E, or losartan not only did not decrease these parameters, but also increased them significantly (P<0.05). The serum level of superoxidase dismutase (SOD) was reduced by CP (P<0.05), but it was increased when estradiol or estradiol plus vitamin C or losartan were added (P<0.05). Conclusion. The particular pharmacological dose of estrogen used in this study abolish the nephroprotective effects vitamins C and E or losartan against CP-induced nephrotoxicity. |
url |
http://dx.doi.org/10.1155/2012/284896 |
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