Comparative Analysis of B-Cell Receptor Repertoires Induced by Live Yellow Fever Vaccine in Young and Middle-Age Donors

Comparative Analysis of B-Cell Receptor Repertoires Induced by Live Yellow Fever Vaccine in Young and Middle-Age Donors

Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination. In present study we employed 5′RACE UMI-based full length and nearly error-free immunoglobulin profiling to compare plasma cell antibody repertoir...

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Bibliographic Details
Main Authors: Alexey N. Davydov, Anna S. Obraztsova, Mikhail Y. Lebedin, Maria A. Turchaninova, Dmitriy B. Staroverov, Ekaterina M. Merzlyak, George V. Sharonov, Olga Kladova, Mikhail Shugay, Olga V. Britanova, Dmitriy M. Chudakov
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
immunoglobulin repertoire
vaccination
age
yellow fever
plasma cell
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02309/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02309/full

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