Contribution of social isolation, restraint, and hindlimb unloading to changes in hemodynamic parameters and motion activity in rats.

The most accepted animal model for simulation of the physiological and morphological consequences of microgravity on the cardiovascular system is one of head-down hindlimb unloading. Experimental conditions surrounding this model include not only head-down tilting of rats, but also social and restra...

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Main Authors: Darya Tsvirkun, Jennifer Bourreau, Aurélie Mieuset, Florian Garo, Olga Vinogradova, Irina Larina, Nastassia Navasiolava, Guillemette Gauquelin-Koch, Claude Gharib, Marc-Antoine Custaud
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3388052?pdf=render