IL-17 Induced Autophagy Regulates Mitochondrial Dysfunction and Fibrosis in Severe Asthmatic Bronchial Fibroblasts

IL-17 Induced Autophagy Regulates Mitochondrial Dysfunction and Fibrosis in Severe Asthmatic Bronchial Fibroblasts

The accumulation of fibroblasts, their synthesis of extracellular matrix (ECM) proteins and their innate resistance to apoptosis are characteristics of subepithelial fibrosis observed in severe asthma. Interleukin-17 (IL-17) is an important regulator of airway remodeling in asthma. However, the cont...

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Bibliographic Details
Main Authors: Rakhee K. Ramakrishnan, Khuloud Bajbouj, Saba Al Heialy, Bassam Mahboub, Abdul Wahid Ansari, Ibrahim Y. Hachim, Surendra Rawat, Laila Salameh, Mahmood Y. Hachim, Ronald Olivenstein, Rabih Halwani, Rifat Hamoudi, Qutayba Hamid
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
severe asthma
bronchial fibroblasts
mitochondria
autophagy
IL-17
fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01002/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01002/full

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