IL-17 Induced Autophagy Regulates Mitochondrial Dysfunction and Fibrosis in Severe Asthmatic Bronchial Fibroblasts
The accumulation of fibroblasts, their synthesis of extracellular matrix (ECM) proteins and their innate resistance to apoptosis are characteristics of subepithelial fibrosis observed in severe asthma. Interleukin-17 (IL-17) is an important regulator of airway remodeling in asthma. However, the cont...
Main Authors: | Rakhee K. Ramakrishnan, Khuloud Bajbouj, Saba Al Heialy, Bassam Mahboub, Abdul Wahid Ansari, Ibrahim Y. Hachim, Surendra Rawat, Laila Salameh, Mahmood Y. Hachim, Ronald Olivenstein, Rabih Halwani, Rifat Hamoudi, Qutayba Hamid |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-05-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01002/full |
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