Enhanced BCR signaling inflicts early plasmablast and germinal center B cell death

Enhanced BCR signaling inflicts early plasmablast and germinal center B cell death

Summary: It is still not clear how B cell receptor (BCR) signaling intensity affects plasma cell (PC) and germinal center (GC) B cell differentiation. We generated Cγ1Cre/wtPtpn6fl/fl mice where SHP-1, a negative regulator of BCR signaling, is deleted rapidly after B cell activation. Although immuni...

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Bibliographic Details
Main Authors: Juan Carlos Yam-Puc, Lingling Zhang, Raul A Maqueda-Alfaro, Laura Garcia-Ibanez, Yang Zhang, Jessica Davies, Yotis A Senis, Michael Snaith, Kai-Michael Toellner
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:iScience
Subjects:
Immunology
immune system
cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221000067

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http://www.sciencedirect.com/science/article/pii/S2589004221000067

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