Enhanced BCR signaling inflicts early plasmablast and germinal center B cell death
Summary: It is still not clear how B cell receptor (BCR) signaling intensity affects plasma cell (PC) and germinal center (GC) B cell differentiation. We generated Cγ1Cre/wtPtpn6fl/fl mice where SHP-1, a negative regulator of BCR signaling, is deleted rapidly after B cell activation. Although immuni...
Main Authors: | Juan Carlos Yam-Puc, Lingling Zhang, Raul A Maqueda-Alfaro, Laura Garcia-Ibanez, Yang Zhang, Jessica Davies, Yotis A Senis, Michael Snaith, Kai-Michael Toellner |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-02-01
|
Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221000067 |
Similar Items
-
YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation
by: Grenov, A., et al.
Published: (2022) -
Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved]
by: Juan Carlos Yam-Puc, et al.
Published: (2018-04-01) -
Germinal center expansion but not plasmablast differentiation is proportional to peptide-MHCII density via CD40-CD40L signaling strength
by: Dustin, M.L, et al.
Published: (2022) -
Pregnancy Downregulates Plasmablast Metabolic Gene Expression Following Influenza Without Altering Long-Term Antibody Function
by: Dominika Swieboda, et al.
Published: (2020-08-01) -
CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function
by: Angeline Rouers, et al.
Published: (2021-05-01)